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The advancements in distributed computing have driven the emergence of service-based infrastructures that allow for on-demand provision of ICT assets. Taking into consideration the complexity of distributed environments, significant challenges exist in providing and managing the offered on-demand resources with the required level of Quality of Service (QoS), especially for real-time interactive multimedia applications. Common to these applications is the service-oriented approach being followed, thus applications consist of application service components that interact in order to provide the corresponding application functionality. In this paper we present an architectural design of a complete Workflow Management System (WfMS) for enacting application service components that have been deployed in a Virtualized Environment. The WfMS aims at synchronizing the application components, monitoring their execution and handling faults while adhering to the QoS requirements of the application.