By Topic

A novel multiparametric microphysiometry system for dynamic cell culture monitoring

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

7 Author(s)
Weltin, A. ; Dept. of Microsyst. Eng., Univ. of Freiburg, Freiburg, Germany ; Kieninger, J. ; Urban, G. ; Moser, I.
more authors

A novel microphysiometry platform for dynamic cell culture monitoring in drug screening and cancer cell research is presented. The transparent system features an integrated cell cultivation area, microfluidics and (bio-)sensors for multiparametric metabolic monitoring, combined on a single glass chip. The parameters include glucose and lactate (amperometric biosensors), oxygen (amperometric), pH (potentiometric) and cellular adhesion (interdigital electrode). In contrast to traditional silicon chip based systems, the choice of transparent materials allows microscopy at all times of cell cultivation and measurement. The introduction of biosensors allows the monitoring of additional key metabolic parameters with a detection limit for lactate as low as 2 μM. Integrated multi layer microfluidics enable dynamic measurements, further improving the analytical performance. The modular system is microfabricated in a cost-effective hybrid integration of thin film and laminate technology.

Published in:

Sensors, 2010 IEEE

Date of Conference:

1-4 Nov. 2010