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Subcarrier and power allocation plays an important part in optimizing the performance of OFDMA systems. However, inter-cellular interference is often neglected in resource allocation. In this paper, with the inter-cell interference taken into account, we propose a subcarrier and power allocation framework based on Game Theory in uplink OFDMA multi-cellular systems. In this algorithm, the subcarrier allocation is based on the normalized channel gain, and the power allocation is achieved by the pricing function. The existence of Nash Equilibrium is proved, and the effect of the algorithm in this paper is discussed about its iterative property and cost factors. Simulation results demonstrate that the inter-cell interference can virtually affect the system performance, and the proposed algorithm could achieve better fairness in users.