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Spatial variation of SNR in two- and three-dimensional neuro-PET

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2 Author(s)
Li, H.J. ; Dept. of Radiol., Emory Univ., Atlanta, GA, USA ; Votaw, J.T.

A method for region of interest (ROI) evaluation for three-dimensional (3-D) positron emission tomography (PET) in the sinogram space was implemented, according to the fully 3-D filtered back-projection algorithm. With this method, the statistical error in the image that propagates from the Poisson noise in the raw data was computed. The signal-to-noise ratio (SNR) for ROIs at various locations inside a cylindrical phantom was computed from both scanner data and simulation data and was verified via the standard deviation method through multiple measurements. As a comparison, two-dimensional (2-D) scans were also collected and similar computations carried out, Results show that the SNR increases with radius due to decreased attenuation at the edge of the phantom. For 3-D scans, the SNR drops gradually for ROIs outside the central 8 cm of the field of view (FOV). Also, it was found that the random events must be recorded and considered in the error computation

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Nuclear Science, IEEE Transactions on  (Volume:44 ,  Issue: 2 )