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Omnidirectional Actuation of Magnetically Driven Microtool for Cutting of Oocyte in a Chip

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4 Author(s)
Inomata, N. ; Dept. of Bioeng. & Robot., Tohoku Univ., Sendai, Japan ; Mizunuma, T. ; Yamanishi, Y. ; Arai, F.

In this paper, we developed and fabricated a magnetically driven microtool (MMT) and installed it on a microfluidic chip for use in the enucleation of oocytes. The fabricated tool is much smaller than a conventional mechanical micromanipulator used for cell manipulation. We succeeded in driving this MMT in two degrees of freedom-in the X- and Y-directions. The MMT works on the principle of noncontact actuation by magnetic force; therefore, the microfluidic-chip part is fully disposable and inexpensive. The MMT consists of a polymer part with a controllable attitude and a rigid metal (Ni) part with good magnetic properties, which are useful for cutting oocytes. We analytically evaluated that the structure for easy attitude control of the polymer part is a four-leg-type configuration. Based on the novel and original design, the MMT and microfluidic chip were fabricated by photolithography. The MMT could generate a force of 3 mN, which is sufficient to cut an oocyte into half. We successfully demonstrated the cutting of an oocyte on a microfluidic chip by using the MMT.

Published in:

Microelectromechanical Systems, Journal of  (Volume:20 ,  Issue: 2 )