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Fractional Frequency Reuse (FFR) is one of the key concepts for mitigating inter-cell interference and improving cell-edge performance in OFDMA networks. The standard FFR scheme is intuitive and optimal for the hexagon-shaped cell pattern. In contrast, real-life OFDMA systems have very irregular cell layout, thus the number of surrounding cells and their respective interference vary significantly over the network. For such scenarios, the standard scheme, if applicable at all, is inadequate because the number of sub-bands and the reuse factor are fixed. To overcome the limitations, we present enhanced FFR (EFFR) that allows for high flexibility in the total number of sub-bands as well as the allocation of sub-bands in edge zones. An optimization algorithm is developed to determine sub-band allocation to maximize the cell-edge throughput. Hence EFFR adapts the allocation and reuse pattern to the irregularity of each individual network. Evaluations based on networks with realistic radio propagation conditions show the high performance of EFFR in improving cell-edge throughput. The improvement allows for better trade-off between cell-center and cell-edge throughput. These results along with the analysis demonstrate the benefits of EFFR to performance engineering of OFDMA networks.