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Discrete-event simulation (DES) has mainly been used as a production system analysis tool to evaluate new production system concepts, layout and control logic. Recent developments have made DES models feasible for use in the day-to-day operational production and planning of manufacturing facilities. Operative simulation models provide manufacturers with the ability to evaluate the capacity of the system for new orders, unforeseen events such as equipment downtime, and changes in operations. A simulation-based Decision Support System (DSS) can be used to help planners and schedulers organize production more efficiently in the turbulent global manufacturing. This paper presents the challenges for development and the efforts to overcome these challenges for the simulation-based DSS. The major challenges are: 1) data integration 2) automated simulation model creation and updates and 3) the visualization of results for interactive and effective decision making. A recent case study is also presented.