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A new grid application management system (GAMS) is proposed in this paper, which is based on globus. GAMS adopts three-tier architecture to combine grid resources, grid services and grid users organically. In our system, geographically distributed resources are shared and intensive applications are managed very well. Single sign-on and unified authentication mechanisms are also realized based on the digital certificates. In addition, effective data management is implemented in our system, including safe and fast data transfer, replicas location and so on. Hot-swapping application management strategy is employed to improve the disaster recovery capabilities, scalability and flexibility of the system. In the end, we take the e-Space Weather Grid system as an example to validate GAMS. It is easy to find that GAMS is efficient and convenient.