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With the development of microelectronics, computer technology, information technology, and intelligent of machinery and control equipment, the flexible manufacturing technique has become one of the key developing directions for advanced manufacturing technology. The cloud manufacturing (CMfg), which is a new generation service-oriented networked manufacturing model, can provide the users distributed in different places with the manufacturing resource and manufacturing ability services through the centralized management. In order to improve the quality of resource service optimal-allocation and cope with the flexible issues in CMfg, this paper investigated the definition and classification of flexibility in the whole life-cycle of resource service composition in CMfg, and the related factors in life-cycle of resource service composition were analyzed. The flexible management architecture for resource service composition in CMfg was designed. The key issues and their solutions in flexible management of resource service composition were preliminarily discussed.