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Pulsed laser triggered high speed fluorescence activated microfluidic switch

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6 Author(s)
Ting-Hsiang Wu ; Dept. of Electr. Eng., Univ. of California at Los Angeles (UCLA), Los Angeles, CA, USA ; Yue Chen ; Sung-Young Park ; Hur, Soojung Claire
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We report a high speed fluorescence activated microfluidic switch capable of achieving a switching time of 50 μsec with a detection efficiency of 86.6% and a switching efficiency of 86.5% at a particle flow speed of ~0.7 m/s. The switching mechanism is realized by exciting dynamic vapor bubbles with focused laser pulses in a microfluidic PDMS channel. The explosive bubble expansion generates fast fluid flows which are directed into a neighboring particle channel to switch the particle flow. Fluorescence activated switching of 10 micron polystyrene microspheres in a Y channel has been demonstrated. This ultrafast laser triggered switching mechanism has the potential to advance the sorting speed of the state-of-the-art microscale fluorescent activated cell sorting devices.

Published in:

Optical MEMS and Nanophotonics (OPT MEMS), 2010 International Conference on

Date of Conference:

9-12 Aug. 2010

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