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A new shift register employing bottom-gate In-Ga-Zn-O thin-film transistors (IGZO TFTs) was proposed and fabricated. Depletion-mode IGZO TFTs were successfully turned off by employing two low-voltage-level signals. The IGZO shift register exhibited a high-voltage output pulse without any distortion and a maximum clock frequency of 417 kHz. The proposed shift register would be an important building block for a depletion-mode oxide TFT display.