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This paper proposes the solution of information service and management based on China Next Generation of Internet (CNGI) for the regional sustainable development in the Great Mekong Subregion (GMS), especially in the Yunnan Province of China at this stage. The platform and the technical standards of information service and management are developed. The platform is consisted of next generation of the Regional Information Infrastructure Network (RIIN) and the seven application systems. It can provide the following main functions of information service and management, such as (1) on-line monitoring of the regional resources and environment; (2) decision support for regional sustainable development; (3) quasi real-time early warning of the regional natural disasters; (4) monitoring and evaluation of the regional bio-diversity and ecological security; (5) gene information service for the regional minority; (6) early warning and control prevention of the regional infectious disease and epidemic disease; (7) information service of the regional tour; (8) monitoring and management of the regional information network and service.