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The mechanism of active counter-attack on worms has been developed and studied for several years. The worm vaccination, a kind of active counter-attack on worms, has some preliminary results. But further research is still required. In this work, we explored a new vaccine to promote the release time through ana-lyzing the structure proposed by Castaneda F, and presented its structure and generation method. The new vaccine is evaluated by Blaster, Nachi and Sasser worm. It shows that the proposed vaccine reduces the release time up to 71% and is applied to worm vaccination successfully.