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This paper deals with multifractal characterization of skin cancer in ultrasound images. The proposed method establishes a multifractal analysis framework of such images based on a new multiresolution indicator, called the maximum wavelet coefficient, derived from the wavelet leaders. Two main contributions are brought up: first, it proposes a method for the estimation of multifractal features. Second, it reveals the potential of multifractal features to characterize skin melanoma. In order to study the efficiency of our maximum coefficient estimator, we compare its results on a simulated image against wavelet leaders based estimator. We then apply the approach on various samples from different skin images. Results show that the extracted features make a promising quantitative indicator to distinguish between different tissues.