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Bacteriophage lambda-mediated gene transfer into human AGS cell line

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3 Author(s)
Khalaj-Kondori, M. ; Dept. of Genetics, Tarbiat Modares Univ., Tehran, Iran ; Sadeghizadeh, M. ; Behmanesh, M.

Bacteriophage lambda particle has dimensions similar to those of many mammalian viruses and recent structural evidences revealed a shared ancestry between tailed bacteriophages and mammalian DNA viruses. Considering these features as well as the double-stranded nature of its genome, bacteriophage lambda might comprise a great advantage for phage-mediated gene delivery into eukaryote cells. A recombinant lambda phage, bearing reporter gene GFP (λ-GFP) was constructed and utilized to transfect AGS cell line. λ-GFP particle-mediated GFP expression as well as their internalization by AGS cell line was investigated.

Published in:

Chemical, Biological and Environmental Engineering (ICBEE), 2010 2nd International Conference on

Date of Conference:

2-4 Nov. 2010