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This paper presents an in-depth analysis of the impact of system noise on large-scale parallel application performance in realistic settings. Our analytical model shows that not only collective operations but also point-to-point communications influence the application's sensitivity to noise. We present a simulation toolchain that injects noise delays from traces gathered on common large-scale architectures into a LogGPS simulation and allows new insights into the scaling of applications in noisy environments. We investigate collective operations with up to 1 million processes and three applications (Sweep3D, AMG, and POP) with up to 32,000 processes.We show that the scale at which noise becomes a bottleneck is system-specific and depends on the structure of the noise. Simulations with different network speeds show that a 10x faster network does not improve application scalability. We quantify noise and conclude that our tools can be utilized to tune the noise signatures of a specific system.