Referenced Items are not available for this document.
This article presents a broad overview of techniques, both analytical and technological, that are used in systems biology to analyze large-scale data sets. While focusing on the computational aspects, the associated biology of cell regulation is also discussed. Discussions are centered around two widely used high-throughput technologies, namely, DNA microarrays and MS-based proteomics. The biological principles behind these techniques are presented. Typical steps involved in generation of high-throughput data to final biological interpretations of analyzed results are discussed. Various attempts to derive systems-level biological networks utilizing microarray and proteomics data are also presented.
Published in:
Control Systems, IEEE
(Volume:30
,
Issue:
6
)
Date of Publication: Dec. 2010
- Page(s):
- 81 - 100
- ISSN :
- 1066-033X
- INSPEC Accession Number:
- 11721653
- Digital Object Identifier :
- 10.1109/MCS.2010.938100
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 22 November 2010
- Issue Date :
- Dec. 2010
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