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Quadrupoles in the fragment separator region of the Facility for Rare Isotope Beams (FRIB) will be subjected to very large heat loads (over 200 Watts) and an intense level of radiation (~10 MGy per year) into the coils of just the first magnet. Magnets made with High Temperature Superconductors (HTS) are advantageous over conventional superconducting magnets since they can remove these heat loads more efficiently at higher temperatures. The proposed design is based on second generation (2G) HTS which allows operation at ~50 K. 2G has been found to be highly radiation tolerant. The latest test results are summarized. The goal of this R&D program is to evaluate the viability of HTS in a real machine with magnets in a challenging environment where HTS offers a unique solution.