By Topic

Kinetic studies on the interaction between EGFR and EGF and its traditional Chinese medicine-modulation by surface plasmon resonance

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
Guo-Chung Dong ; Div. of Med. Eng. Res., Nat. Health Res. Institutes, NHRI, Zhunan, Taiwan ; Chun-Hsu Yao

Epidermal growth factor receptor (EGFR) is an important target on cancer therapy. One of the approaches is to modulate EGFR induced ligand-binding affinity change. In order to understand the correlation between ligand-binding change and EGFR modulation, we try to get some small molecular agents from traditional Chinese medicines (TCMs) to modulate EGFR activity on the biosensor system. Among 60 of TCMs, we find that some samples exhibit different influence on EGFR modulation. Among these, 051 showed a more inhibitive property due to decreasing EGF-affinity, -binding to EGFR and existed an anti-EGFR activity to A549 cells. On the other hand, 040 exist opposite function to 051. 040 is a most powerful enhancer that can increase the affinity and quantity of EGF binding to EGFR and a pro-EGFR activity on cell culture system. In our study, we can successfully regulate the EGFR-mediated cell proliferation and anti-apoptosis by modulating the affinity of EGF-EGFR interaction. This way will be a useful method to apply on the therapy of human diseases.

Published in:

Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on  (Volume:6 )

Date of Conference:

16-18 Oct. 2010