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Numerical Simulation of the interaction between Intracranial Pressure (ICP) and Cerebral Blood Flow (CBF) based on physiology and hemodynamics is presented. The circulation of the cerebral blood and the circulation of the cerebrospinal fluid are considered in this model. The model includes the main biomechanical factors assumed to affect intracranial pressure, particularly cerebrospinal fluid (CSF) dynamics, intracranial compliance, and cerebral hemodynamics, which is in accordance with the fact. We can list some state equations on the basis of the model, which can be solved using MATLAB. Comparison between the experimental recordings and simulated intracranial pressure signals shows that they are consistent and there is a correlation between the intracranial pressure and the arterial pressure, proving the validity of the model. This paper provides an assistant method for clinic noninvasive monitoring intracranial pressure.