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A study is presented of wireless on-body communication links, with the body in motion. This paper compares simulations and measurements of the path gain (PG) on moving male and female bodies. Simulations using avatars derived from an animation software have been performed at 2.45 GHz. Male and female avatars walking and a male rising from a chair have been simulated and the results are compared with measurements carried out in an anechoic chamber. The results show that good agreement between simulation and measurement of slow fading features can be achieved for a reasonable computational effort.