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This paper presents a proposal for a context-aware framework for alert generation. The framework is organized according to a general purpose agent-based architecture, centered around an ontological context representation. The ontology provides the vocabulary upon which software agents interoperate and perform rule-based reasoning. The system components and their coordinated operations are described and a challenging application in the home-care scenario is presented. Customization efforts and validation numerical results are provided in such real-life scenario, thus demonstrating the effectiveness of the implemented framework.