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Multi-Channel SQUID-Based Ultra-High-Sensitivity In-Vitro Detections for Bio-Markers of Alzheimer's Disease Via Immunomagnetic Reduction

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12 Author(s)
Chiu, M.J. ; Dept. of Neurology, Nat. Taiwan Univ., Taipei, Taiwan ; Horng, H.E. ; Chieh, J.J. ; Liao, S.H.
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Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

Published in:

Applied Superconductivity, IEEE Transactions on  (Volume:21 ,  Issue: 3 )

Date of Publication:

June 2011

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