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Significant progress has been made in energy conservation and consumption reduction since the 11th Five-year Plan. 600MW-class thermal power units have become the main force in China's power mix. It is crucial to study the energy-saving potential, improve the economic operation and overall competitiveness of 600MW power units. Taking a 600MW power unit of certain power corporation for instance, the energy-loss analysis method was introduced to analyze the energy efficiency and energy-saving potential of 600MW power unit. Based on this, several optimized solutions were performed, focusing on the combustion optimization, slide-pressure operation optimization, sequence valve control optimization and gland seal retrofit etc.. This made favorable energy-saving effects, reducing the coal consumption greatly.