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This paper has designed a distributed monitoring and diagnosis system of engine locomotive. Diagnosis Unit which collecting the real-time parameter data such as GPS information and on-line diagnosis messages for locomotive diesel engine, is installed in each locomotive. It transmits data to the Data Transfer Station via GPRS module. Meanwhile, the Data Transfer Station is used as FTP server on Internet for the Diagnostic Center mining. Authorized clients can get the comprehensive diagnosis conclusion of each locomotive though the website visit of the Diagnostic Center. This system has been finished in the laboratory, and a model system has been established in the Wunan Locomotive Depot, Wuhan Railway Bureau. The application and promotion of the system will greatly advance the maintenance and management level of the engine locomotive.