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Using pre-treatment EEG data to predict response to SSRI treatment for MDD

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5 Author(s)
Khodayari-Rostamabad, A. ; Electr. & Comput. Eng. Dept., McMaster Univ., Hamilton, ON, Canada ; Reilly, J.P. ; Hasey, G. ; de Bruin, H.
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The problem of identifying in advance the most effective treatment agent for various psychiatric conditions remains an elusive goal. To address this challenge, we propose a machine learning (ML) methodology to predict the response to a selective serotonin reuptake inhibitor (SSRI) medication in subjects suffering from major depressive disorder (MDD), using pre-treatment electroencephalograph (EEG) measurements. The proposed feature selection technique is a modification of the method of Peng et al [10] that is based on a Kullback-Leibler (KL) distance measure. The classifier was realized as a kernelized partial least squares regression procedure, whose output is the predicted response. A low-dimensional kernelized principal component representation of the feature space was used for the purposes of visualization and clustering analysis. The overall method was evaluated using an 11-fold nested cross-validation procedure for which over 85% average prediction performance is obtained. The results indicate that ML methods hold considerable promise in predicting the efficacy of SSRI antidepressant therapy for major depression.

Published in:

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Date of Conference:

Aug. 31 2010-Sept. 4 2010