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Multimodality image registration is a critical issue in image-guided cancer ablation techniques. Focal therapies of prostate cancer are usually monitored using ultrasound imaging, while the dose planning is performed on MRI. In this study, a new multimodality images registration and deformation method, based on the Thin Plate Splines -Rigid Point Matching (TPS-RPM) algorithm, is introduced. The Method combines non-rigid mapping and interpolation to deform the images. Preliminary results obtained on phantom and clinical images showed that the registration is accurate and robust against landmarks initialization.