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In vivo snapshot hyperspectral image analysis of age-related macular degeneration

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8 Author(s)
N. Lee ; Heffner Biomedical Imaging Laboratory (HBIL) and the Department of Biomedical Engineering, Columbia University, New York, 10027 USA ; J. Wielaard ; A. A. Fawzi ; P. Sajda
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Drusen, the hallmark lesions of age related macular degeneration (AMD), are biochemically heterogeneous and the identification of their biochemical distribution is key to the understanding of AMD. Yet the challenges are to develop imaging technology and analytics, which respect the physical generation of the hyperspectral signal in the presence of noise, artifacts, and multiple mixed sources while maximally exploiting the full data dimensionality to uncover clinically relevant spectral signatures. This paper reports on the statistical analysis of hyperspectral signatures of drusen and anatomical regions of interest using snapshot hyperspectral imaging and non-negative matrix factorization (NMF). We propose physical meaningful priors as initialization schemes to NMF for finding low-rank decompositions that capture the underlying physiology of drusen and the macular pigment. Preliminary results show that snapshot hyperspectral imaging in combination with NMF is able to detect biochemically meaningful components of drusen and the macular pigment. To our knowledge, this is the first reported demonstration in vivo of the separate absorbance peaks for lutein and zeaxanthin in macular pigment.

Published in:

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology

Date of Conference:

Aug. 31 2010-Sept. 4 2010