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In this paper, we propose a low-complexity interference cancellation (IC) scheme for OFDMA uplink systems with CFOs. The proposed scheme employs a multi-stage structure, in which a subcarrier-grouped MMSE scheme is used in each stage. To make the proposed scheme more flexible to the tradeoff between the performance and the complexity, we generalize the subcarrier-grouped MMSE scheme and employ a novel IC strategy. The simulation results show that the proposed IC scheme outperforms other existing schemes with considerable low complexity.