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In this paper we present a comprehensive simulation framework that can accurately simulate our indoor UWB positioning system including the analog front-ends, digital back-ends, and channel effects. Experimental results from our UWB positioning system are compared to simulated results to validate the accuracy of the simulation framework. Simulated results illustrate the design decisions made in optimizing overall system performance. Multiple peak detection algorithms are presented, and the robustness of our leading-edge detection algorithm is shown even in dense multipath environments. Geometric effects are examined by simulating various base station configurations. This comprehensive simulation framework provides an in-depth analysis of our UWB positioning system and also provides a general framework for rapid prototyping and design of complex wireless systems.