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Power consumption has become one of most serious challenges for SoC design. Among the various methods, Multiple Supply Voltage (MSV) is an effective method for power reduction. In this paper, Genetic Algorithm (GA) is used to optimize the Voltage Islands-Aware Multiple Voltage Assignment (VIAMVA). A cost function is developed to take the overhead of level shifters and the complexity of power network into account. The proposed algorithm is tested on six GSRC benchmarks. Experimental results show that the proposed method can save power consumption up to 47.60% with voltage island generation.