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Compact Voltage and Current Stimulation Buffer for High-Density Microelectrode Arrays

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5 Author(s)
Paolo Livi ; Bio Engineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basle, Switzerland ; Flavio Heer ; Urs Frey ; Douglas J. Bakkum
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We report on a compact (0.02 mm2 ) buffer for both voltage and current stimulation of electrogenic cells on a complementary metal-oxide semiconductor microelectrode array. In voltage mode, the circuit is a high-current class-AB voltage follower, based on a local common-mode feedback (LCMFB) amplifier. In current mode, the circuit is a current conveyor of type II, using the same LCMFB amplifier with cascode stages to increase the gain. The circuit shows good linearity in the 0.5-3.5 V input range and has extensively been used for stimulation of neuronal cultures.

Published in:

IEEE Transactions on Biomedical Circuits and Systems  (Volume:4 ,  Issue: 6 )