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This paper presents novel digital signal processing algorithms for linearizing PAs and correcting RF impairments in multi-standard, multi-mode, and multi-band wireless communication transceiver platforms. Traditional analog/RF radio architectures must often trade-off power efficiency (as in the case of power amplifiers) and/or board area, system cost and complexity to meet multi-standard performance requirements. Advances in digital signal processing capabilities and algorithms have now enabled digitally assisted RF radio systems to truly meet multi-standard performance requirements while providing unprecedented improvements in power efficiency and system cost as a whole. In this paper, we introduce an integrated transmit and receive digital signal processing solution which provides compensation for key RF system chain impairments such as linear/non-linear distortion, IQ imbalance, and DC offset/LO feedthrough. In addition, this chip provides a state of the art power amplifier linearization solution including crest factor reduction and digital pre-distortion for a variety of power amplifier topologies, including advanced Doherty and envelope tracking. This solution also includes digital up/down conversion, automatic gain control algorithms, solutions to support frequency hopping signals, and novel PA protection features, all in a compact 23×23mm BGA ASSP, with under 4W of power consumption.