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In order to predict the cost, a model of cost prediction was set up based on adaptive hierarchical genetic algorithm and RBF neural network. Hierarchical genetic algorithm could optimize the topology and the parameters simultaneously. Compared with simple genetic algorithm, it has more efficiency in not only accelerating and stabilizing the parameters training but also determining the structure of the network. Adaptive crossover and mutation probability could accelerate the speed and avoid prematurity. The model was tested by five samples. The results showed that the prediction model has high prediction accuracy, which indicated that it was applicable to predict the cost by the model.