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Variable Time-Delay Estimation for Anesthesia Control During Intensive Care

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3 Author(s)
Ionescu, C.M. ; Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium ; Hodrea, R. ; De Keyser, R.

The presence of artifacts plays a crucial role in automatic sedation systems and may introduce variable time delays (TDs) in the closed-loop-control structures. This paper presents a successful procedure to estimate the varying TD of the bispectral index (BIS) monitor used in closed-loop control during intensive care. The TD estimation (TDE) is based on the cross-correlation analysis technique and the method is validated with real measured signals of propofol and BIS. Extended prediction self-adaptive control is used in combination with a Smith predictor to reduce the computational burden imposed by the variable TD. The conclusion is that an online TDE of the BIS monitor improves the performance of the closed-loop system for reference tracking, disturbance rejection, and overall stability.

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Biomedical Engineering, IEEE Transactions on  (Volume:58 ,  Issue: 2 )