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A low power highly sensitive Thoracic Impedance Variance (TIV) and Electrocardiogram (ECG) monitoring SoC is designed and implemented into a poultice-like plaster sensor for wearable cardiac monitoring. 0.1 Ω TIV detection is possible with a sensitivity of 3.17 V/Ω and SNR > 40 dB. This is achieved with the help of a high quality (Q-factor > 30) balanced sinusoidal current source and low noise reconfigurable readout electronics. A cm-range 13.56 MHz fabric inductor coupling is adopted to start/stop the SoC remotely. Moreover, a 5% duty-cycled Body Channel Communication (BCC) is exploited for 0.2 nJ/b 1 Mbps energy efficient external data communication. The proposed SoC occupies 5 mm × 5 mm including pads in a standard 0.18 μm 1P6M CMOS technology. It dissipates a peak power of 3.9 mW when operating in body channel receiver mode, and consumes 2.4 mW when operating in TIV and ECG detection mode. The SoC is integrated on a 15 cm × 15 cm fabric circuit board together with a flexible battery to form a compact wearable sensor. With 25 adhesive screen-printed fabric electrodes, detection of TIV and ECG at 16 different sites of the heart is possible, allowing optimal detection sites to be configured to accommodate different user dependencies.