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DNA detection using a complementary metal-oxide semiconductor ring oscillator circuit

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2 Author(s)
Kocanda, M. ; Department of Electrical Engineering, Northern Illinois University, DeKalb, Illinois 60115, USA ; Abdel-Motaleb, Ibrahim

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A DNA detection scheme has been implemented that utilizes a simple complementary metal-oxide semiconductor (CMOS) ring oscillator circuit. The detector oscillates at a fundamental frequency when using a nonhybridized single-strand DNA probe layer. Upon hybridization with a complimentary DNA strand, the oscillator output exhibits an increased frequency shift, indicating a genetic match. The probe assembly consists of a p-GaAs substrate containing a pulsed laser deposition-applied barium strontium titanate layer and an overlying sodium dodecyl sulfate lipid layer that serves to anchor a functionalized oligonucleotide probe. The oscillator circuit consisting of cascaded discrete complimentary n-channel and p-channel metal-oxide-semiconductor field-effect transistors was implemented using passive components arranged in a T-network to provide the associated fundamental time constant.

Published in:

Journal of Applied Physics  (Volume:108 ,  Issue: 7 )