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Theoretical and experimental study of electroporation of red blood cells using MEMS technology

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5 Author(s)
Deng, Peigang ; KAUST-HKUST Joint Micro/Nanofluidics Lab., Hong Kong Univ. of Sci. & Technol., Hong Kong, China ; Guangyao Yin ; Zhang, Tong-Yi ; Chang, D.C.
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A theoretical and experimental study of electroporation (EP) of red blood cells (RBCs) was presented in this paper. With additional strain energy, an energy-based model of an electropore induced on a RBC's membrane at different electric fields was proposed to predict the critical EP electric field strength. In addition, EP experiments with red blood cells at single-cell level was carried out on a micro EP chip. The measured critical EP electric field strengths are in agreement with the numerical predictions.

Published in:

Nano/Micro Engineered and Molecular Systems (NEMS), 2010 5th IEEE International Conference on

Date of Conference:

20-23 Jan. 2010