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Based on the concepts and principles of quantum computing, a novel clustering algorithm, called a quantum-inspired immune clonal clustering algorithm based on watershed (QICW), is proposed to deal with the problem of image segmentation. In QICW, antibody is proliferated and divided into a set of subpopulation groups. Antibodies in a subpopulation group are represented by multi-state gene quantum bits. In the antibody's updating, the quantum mutation operator is applied to accelerate convergence. The quantum recombination realizes the information communication between the subpopulation groups so as to avoid premature convergences. In this paper, the segmentation problem is viewed as a combinatorial optimization problem, the original image is partitioned into small blocks by watershed algorithm, and the quantum-inspired immune clonal algorithm is used to search the optimal clustering centre, and make the sequence of maximum affinity function as clustering result, and finally obtain the segmentation result. Experimental results show that the proposed method is effective for texture image and SAR image segmentation, compared with the genetic clustering algorithm based on watershed (W-GAC), and the k-means algorithm based on watershed (W-KM).