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A well-known problem in stereoscopic images is visual fatigue. In order to reduce visual fatigue, we propose depth adjustment method which controls the amounts of parallax of stereoscopic images by using visual fatigue prediction and depth-based view synthesis. We predict the visual fatigue level by examining the horizontal and vertical disparity characteristics of 3D images, and if the contents are judged to contain visual fatigue, depth adjustment is applied by using depth-based view synthesis. We present a method for extracting disparity characteristics from sparse corresponding features. Depth-based view synthesis algorithm is proposed to handle the hole regions in rendering process. We measured the correlations between visual fatigue prediction metrics and the subjective results, acquiring the ranges of 79% to 85%. Then, we performed depth-based view synthesis to the contents which are predicted to cause visual fatigue. A subjective evaluation showed that the proposed depth adjustment method generated comfortable stereoscopic images.