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From a cross-layer perspective in distributed antenna systems, system throughput coefficient and fairness coefficient are defined taking into consideration both queue state information in data-link layer and channel state information in physical layer. Particularly, a self organizing map based optimization (SOMO) algorithm is proposed to solve the proposed optimization problem. Through simulations, it was demonstrated that the proposed scheme can obtain lower queue delay. System throughput and fairness performance obtained by the proposed algorithm increase considerably compared with those by fixed power allocation algorithm.