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Interruption from primary users is a key factor impacting the performance of secondary users in cognitive radio networks. Based on a simplified model of primary user interruptions (Markov chain), queuing analysis is carried out for two-server-single-queue and single-server-two-queue cases. A semi-analytic result is obtained for the generating function of queue length in the two-server-single-queue case. The average queue length is obtained from solving a group of linear equations for the single-server-two-queue case. The maximal packet arrival rates versus different service rates and interruption parameters are obtained via numerical simulations.