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Aircraft MDO (Multidisciplinary Design Optimization) needs Grid technology because of complex process and time-consuming design. Specifically, aircraft MDO can benefit from Grid computing in terms of massive computational capacity and resource sharing. However, determining how to manage aircraft MDO processes and how to effectively apply grid technology into aircraft MDO remain as problems, which address the demand of an effective domain specific workflow engine. Different previous works focus on universal workflow engines. In this paper, we propose a Grid-enabled DSWE (Domain Specific Workflow Engine) system for aircraft MDO, which highlights the requirements in aircraft MDO and provides a friendly interface for workflow construction. A practical prototype system of the DSWE has been implemented. We demonstrated the effectiveness of the Grid-enabled DSWE system from performance evaluation and testing results in the case study.