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Plasma medicine is an expanding focus and offers new aspects of therapy combining potent physical partial efficacies, like such as ultraviolet, infrared, and reactive species and particles, and nowadays, many successful treatments of different illnesses have been described. Fungal skin and nail infections pose significant therapeutic and economical problems. To test the plasma susceptibility of clinical strains of the most frequently encountered fungal species involved in dermatomycosis, clinical isolates of Trichophyton interdigitale, Trichophyton rubrum, Microsporum canis, and Candida albicans were irradiated by a cold atmospheric pressure plasma jet. Punctual plasma irradiation eradicated fungal growth of all species with the largest inactivation zones with most progress in the first 15 s of treatment, treating C. albicans and least progress in that of , the lowest being M. canis. No isolate exhibited resistance to plasma treatment. Plasma treatment also completely eradicated reproductive fungal elements of T. interdigitale in dandruff of patients with tinea pedis ex vivo and in the environment in contaminated shoes. Accordingly, cold plasma seems suited to antifungal in vivo treatment of fungal skin infections and decontamination of environmental infective material.