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Summary form only given. Recently new technologies such as cloud computing, massive data processing, and knowledge processing are emerging to enable new ways to build IT infrastructures. On the other hand companies and our society face more and more complex issues today. Accordingly, the number of new IT services that should be designed to address the needs of multiple companies or stakeholders is increasing. On the contrary most IT systems up to now have been designed to satisfy limited business functions within a single enterprise, typically substituting simple human activities. With this in mind, in this keynote a new vision will be introduced that shifts the system design paradigm from IT-centric to human-centric, focusing on “people and society” and the “value and benefit” that they will obtain from IT systems. Also research directions such as “value-based visualization & optimization” and “value-based knowledge processing” that will underpin such new infrastructures under this vision will be discussed.