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Decision support system (DSS) has been applied in a wide range of computer applications that commonly manipulate information in variety fields. This is including computer-based systems that are being used in handling data in order to achieve an optimization for decision-making in crime investigation. Deoxyribonucleic acid (DNA) profile analysis using computer programming is not a new research in biology and information technology. Projects have been done in developed countries and around the world to develop software tools to analyze DNA data. The main purpose for this research is to design a new architecture of integrated system in handling DNA profile match for identifying possible criminal and convicted offenders. Furthermore, a new visual forensic DNA analysis tool will be developed to help criminal investigators to analyze DNA data and DNA profile. Finally, the proposed architecture and software tool will be evaluated. The need of a high performance computing in a time-critical situation presents a challenge to grid environment.