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This paper studies the jitter performance at the input of the transimpedance amplifier (TIA) in a communication system based on multimode optical fibers. A method is shown to analyze and effectively reduce data-dependent jitter by proper choice of the TIA input resistance and the use of multiple feedback techniques. A 40-Gbit/s TIA in 0.25-μm BiCMOS with fT of up to 180 GHz is presented to demonstrate the efficiency of the jitter analysis. It shows 6 kΩ (75.5 dBΩ) transimpedance gain, 37.6-GHz bandwidth, open eyes, and less than 0.6-ps root mean square jitter at 40 Gbit/s, as well as best-in-class power consumption and noise performance.