Cart (Loading....) | Create Account
Close category search window
 

Robust Optimal Reference-Tracking Design Method for Stochastic Synthetic Biology Systems: T–S Fuzzy Approach

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
Chen, Bor-Sen ; Dept. of Electr. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan ; Chih-Hung Wu

At present, the development in the nascent field of synthetic gene networks is still difficult. Most newly created gene networks are nonfunctioning due to intrinsic parameter fluctuations, uncertain interactions with unknown molecules and external disturbances of intra and extracellular environments on the host cell. How to design a completely new gene network, that is to track some desired behaviors under these intrinsic and extrinsic disturbances on the host cell, is the most important topic in synthetic biology. In this study, the intrinsic parameter fluctuations, uncertain interactions with unknown molecules and environmental disturbances, are modeled into the nonlinear stochastic systems of synthetic gene networks in vivo. Four design specifications are introduced to guarantee the stochastic synthetic gene network, which can achieve robust optimal tracking of a desired reference model in spite of these intrinsic and extrinsic disturbances on the host cell. However, the robust optimal reference-tracking design problem of nonlinear synthetic gene networks is still hard to solve. In order to simplify the design procedure of the robust optimal nonlinear stochastic-tracking design for synthetic gene networks, the Takagi-Sugeno (T-S) fuzzy method is introduced to solve the nonlinear stochastic minimum-error-tracking design problem. Hence, the robust optimal reference-tracking design problem under four design specifications can be solved by the linear matrix inequality (LMI)-constrained optimization method using convex optimization techniques. Further, a simple design procedure is developed for synthetic gene networks to meet the four design specifications to achieve robust optimal reference tracking. Finally, an eigenvalue-shifted design method is also proposed as an expedient scheme to improve the stochastic optimal-tracking design method of synthetic gene oscillators.

Published in:

Fuzzy Systems, IEEE Transactions on  (Volume:18 ,  Issue: 6 )

Date of Publication:

Dec. 2010

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.