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Model single ion channel for structure investigation

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2 Author(s)
Fu-Chiang Young ; Dept. of Electr. Eng., Nat. Cheng Kung Univ., Tainan, Taiwan ; Ching-Hsing Luo

This project presents a method to model a single channel from protein sequences provided by common protein sequences databanks. Under single-cell level, concrete protein structures will provide a configuration to simulate structural mechanics. Here a potassium was modeled, voltage-gated channel (Kv channel), to investigate its corresponding mechanics of each subunit. In electrophysiology, the potassium channel is defined as slow delayed rectifier potassium current (Iks) by LRd ventricular cell model which defined completely in 2005. It is constructed from the conformational shape of the Shaker Kv1.2 channel as a template to model single KCNQ1 channel (Kv7.1).

Published in:

Nano/Molecular Medicine and Engineering (NANOMED), 2009 IEEE International Conference on

Date of Conference:

18-21 Oct. 2009