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When IEEE Intelligent Systems solicited ideas for a new department, cyberphysical systems(CPS) received overwhelming support.Cyber-Physical-Social Systems is the new name for CPS. CPSS is the enabling platform technology that will lead us to an era of intelligent enterprises and industries. Internet use and cyberspace activities have created an overwhelming demand for the rapid development and application of CPSS. CPSS must be conducted with a multidisciplinary approach involving the physical, social, and cognitive sciences and that Al-based intelligent systems will be key to any successful construction and deployment.